Low antibody levels against cell wall-attached proteins of Streptococcus pyogenes predispose for severe invasive disease.

Low Antibody Levels against Cell Wall-Attached Proteins of Streptococcus pyogenes

Streptococcus pyogenes strains associated with invasive and non-invasive infections present possible links with emm types and superantigens

Objective(s): Streptococcus pyogenes, a notorious human pathogen is responsible to cause a wide range of infections varies from superficial common clinical illness to severe and life threatening infections. To our knowledge this is the first report exploring the emm types and superantigen/exotoxin gene profile of S. pyogenes from Pakistan. Materials a...

In Silico Investigation for Evaluation of the Potential of the SclA Protein in Streptococcus pyogenes

BACKGROUND Streptococcus pyogenes is an important pathogen that is associated with a range of infections in humans, and causes common and severe invasive diseases. Currently, antimicrobial therapy is the first choice for the treatment of S. pyogenes; however, the emergence of antimicrobial resistance and side effects of antibacterial drugs is increasing. Consequently, there is an increased dema...

Improved pattern for genome-based screening identifies novel cell wall-attached proteins in gram-positive bacteria.

With a large number of sequenced microbial genomes available, tools for identifying groups or classes of proteins have become increasingly important. Here we present an improved pattern for the identification of cell wall-attached proteins (CWPs), a group of proteins with diverse and important functions in gram-positive bacteria. This tripartite pattern is based on analysis of 65 previously des...

The role of streptokinase as a virulence determinant of Streptococcus pyogenes--potential for therapeutic targeting.

Streptococcus pyogenes is a major human pathogen responsible for numerous diseases ranging from uncomplicated skin and throat infections to severe, life threatening invasive disease such as necrotising fasciitis and streptococcal toxic shock syndrome. These severe invasive infections progress rapidly and produce high rates of morbidity and mortality despite the implementation of aggressive trea...